Diatrol 80
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Diatrol is an oral antidiabetic medication from the sulfonylurea group, indicated for adults with type 2 diabetes mellitus when diet, exercise, and weight loss alone do not adequately control blood sugar levels.


Gliclazide, the active ingredient, stimulates insulin release from pancreatic β-cells and reduces hepatic glucose output. It has potential hematological benefits and is considered a second-generation sulfonylurea.


For dosage and administration, the typical initial dose of the film-coated tablets is 40 to 80 mg daily, which may be increased to a maximum of 320 mg daily in divided doses. This medication should be taken before meals. In the case of modified release preparations, the recommended dose is one to four tablets (maximum 120 mg) taken once daily at breakfast. It is important to swallow the tablets whole with a glass of water and not to chew or crush them. Eating after taking the medication is essential.


When used in combination with other antidiabetic agents, the physician will determine the appropriate dosages for each medication. In the event of an overdose, symptoms may indicate hypoglycemia. Immediate intake of sugar is advised, and medical assistance should be sought if severe symptoms occur. If a dose is missed, the next dose should be taken at the usual time without doubling up.


Interactions with Diatrol can enhance its blood sugar-lowering effects when used alongside other oral antidiabetics, GLP-1 receptor agonists, or insulin, as well as certain antibiotics, antihypertensives, antifungals, and painkillers. Conversely, some medications, such as corticosteroids and certain CNS drugs, may weaken Diatrol's effects.


The medication is contraindicated in patients with known allergies to gliclazide or other sulfonylureas, those with insulin-dependent diabetes (type 1), and individuals experiencing diabetic ketoacidosis or severe kidney or liver disease. It is also not recommended for breastfeeding.


Common side effects of Diatrol include hypoglycemia, which may lead to severe symptoms if untreated. Abnormal liver function can result in jaundice, while skin reactions may include rashes or severe allergic responses. Blood disorders may lead to a decrease in blood cell counts, and gastrointestinal issues such as nausea, vomiting, and diarrhea are also possible. Changes in vision may occur, especially at the onset of treatment due to fluctuations in blood sugar levels.

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